Publication Details
Abstract
Pregnancy represents a period of profound physiological changes that orchestrate a complex modulation of maternal immunology system to ensure tolerance of the semi-allogeneic fetus. This delicate balance is fundamental to a successful gestation and is significantly influenced by the immunological compatibility of parents, which can affect maternal recognition and support of the pregnancy. The aims study to detect the main factors for the success of pregnancy and the mother's adaptation to the development of the fetus. A key component for this adaptation involves the functional reprogramming of immune cells, particularly the regulation of Natural Killer (NK) cell activity at the uterine level, shifting their function from cytotoxic to supportive roles in placental development. However, these necessary immune modifications can increase maternal susceptibility to certain pathogens, making the prevention and management of infection during pregnancy a critical clinical concern. Furthermore, this intricate biological interplay is subject to modulation by various the environmental factors, such as diet, stress, and exposure to toxin, which can impact maternal immune status and overall pregnancy outcome. Ultimately, a successful pregnancy depends on the dynamic integration of these physiological, immunological, and environmental variables.