Synthesis and Characterization of New Some Imidazole’s Derivatives as Antioxidants

This research focuses on the synthesis and characterization of two new imidazole derivatives: 2-methoxy-6-[4-(naphthalen-2-yl)-1-phenyl-1H-imidazol-2-yl] and 2-(4-methylphenyl)-4-(naphthalen-2-yl)-1-phenyl-1H-imidazole. The study aimed to explore their antioxidant properties using DPPH radical scavenging assays. The synthesis was achieved by heating a mixture of 2-bromo-2′-acetonaphthone, primary amine, aldehyde, and ammonium acetate in a solvent-free environment at 130°C. The characterization of the compounds was done using FT-IR, 1H-NMR, and mass spectral analysis. The antioxidant activity was evaluated, and both derivatives demonstrated significant radical scavenging properties, with the second compound showing higher inhibition. The results suggest that these imidazole derivatives are potent antioxidants, which could be beneficial for further medicinal applications.