Oxidative Stress in Systemic Lupus Erythematosus Causes Inflammation and Cellular Damage

Systemic lupus erythematosus (SLE) is a complex autoimmune disease affecting various organs, driven by a combination of genetic, environmental, and hormonal factors leading to immunological dysregulation. The disease is characterized by the production of autoantibodies, inflammation, and end-organ damage, with oxidative stress playing a significant role by inducing functional changes in DNA, lipids, and proteins. Current understanding of SLE pathophysiology highlights the importance of oxidative stress biomarkers in predicting disease progression and guiding treatment. Despite available treatments like corticosteroids and immunosuppressants, there remains a need for more effective therapies with fewer side effects. This research aims to investigate the relationship between oxidative stress and SLE progression, utilizing biomarkers to improve early diagnosis and treatment decisions. By analyzing oxidatively modified molecules in SLE patients, the study seeks to enhance our understanding of disease mechanisms and identify new therapeutic targets to reduce morbidity and mortality.