Publication Details
Abstract
Interleukin-18 (IL-18) is a pro-inflammatory cytokine that has been implicated in the regulation of immune responses during pregnancy. Several studies have reported that elevated levels of IL-18 are associated with recurrent miscarriage and spontaneous abortion. IL-18 can induce apoptosis of trophoblast cells, disrupt the balance of Th1/Th2 cytokines, and stimulate the release of pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ). These events can lead to inflammation, oxidative stress, and damage to the developing fetus, resulting in fetal loss. Moreover, genetic variations in the IL-18 gene have been linked to an increased risk of recurrent miscarriage and fetal growth restriction. This study aims to investigate the role of IL-18 gene in spontaneous abortion. Results show elevated levels of IL-18 mRNA using q RT-PCR and also at the protein levels using ELISA techniques. These results are indicative of critical role in regulating the immune response during pregnancy, and aberrant expression or genetic variations in the IL-18 gene may contribute to the pathogenesis of abortion. Further research is needed to elucidate the mechanisms underlying the role of IL-18 in abortion and to explore its potential as a therapeutic target for preventing pregnancy loss