Preparation and Evaluation of Bacterial Activity and Study of the Crystalline Properties of Some 1,3-Oxazepine-4,7-Dione Derivatives

This study prepared N-(4-sulfamoyl phenyl)hydrazinecarbothioamide by reacting para-amino sulfamide, carbon sulfide, and aqueous hydrazine. Next, hydrazones were prepared using benzaldehyde substitutes in the hydrazide reactor, and lastly, the hydrazone reaction was used to create derivatives of 1,3-oxazepine-4,7-dione. utilizing anhydride maleic acid. Using spectroscopic and physical methods (mp, colour, proton nuclear magnetic resonance spectroscopy (1H-NMR, 13C-NMR, and FT-IR) to measure biological activity on different bacteria (e.g., Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, and streptococci) and confirm the structure of compounds. Determine the changes that take place inside the liquid crystals by examining their phases with a polarized optical microscope that is heated.