Synthesis, Diagnosis and Study of Molecular Docking for 4-(4-amino-5-mercapto-4H-1,2,4-triazol-3-yl) Phenol and Its Coordination with Some Metals

Triazol is an important nitrogen heterocyclic compound, containing three nitrogen atoms and two carbon atoms. Where triazole and its complexes were prepared by Acid Hydrazide (A1) was synthesis from the condensation of ester with hydrazine hydrate using ethanol absolute as a solvent. The next step involved the reaction of hydrazide acid, carbon sulfide (CS2), and ethanol to produce oxadazole (A2). Then, haydrazine hydrate was mixed with the triazole (A3) oxadiazole derivative. The complexes A4–A7 were produced by the reaction of the ligand (A3) with binary metal salts of the transition elements Co (II), Ni (II), Cu (II), and Mn (II). The reaction ratio of every complex that was produced was 1:1. The Ligand is Metal. The ligand was described using FT-IR, 1H, 13C-NMR, and elemental analysis (C.H.N.S.M.). The generated compounds were diagnosed using infrared spectroscopy (FT-IR) techniques, magnetic sensitivity at ambient temperature, and other approaches. The results showed that the atoms of sulfur and nitrogen coordinate ligand bidentate. The form of the octahedral complex is as follows