Synthesis and Characterization of New Derivatives of 2,3-Dihydroquinazolin-4-one and Evaluation of their Antibacterial Activity

The present study included the synthesis of heterogeneous compounds of hydroquinazoline by reacting the prepared hydrazones with 2-aminophenol in the presence of ethanol as a solvent. The structures of the formed compounds were confirmed by physical and spectroscopic methods such as infrared spectra and proton and carbon nuclear magnetic resonance spectra (1H, 13C-NMR). The biological activity was evaluated using two types of bacterial isolates known for their resistance to antibiotics, namely Gram-negative Escherichia coli (Gram -ve) and Gram-positive Staphylococcus aureus (Gram +ve), and compared with the antibiotic as a control factor (Controls) Ciprofloxacin. The results showed good inhibitory activity for two types of used bacteria and high effectiveness and selectivity.