Synthesis and Characterization of New Derivatives of The Seven-Ring Oxazepine and Study of Their Bacterial Activity

This article deals with the preparation and characterization of new derivatives of oxazepine compounds using the traditional method of sublimation. This study of this type of seven-membered rings comes due to its wide-ranging pharmacological and biological importance in various medical and pharmaceutical fields. These compounds were prepared by reacting 2-aminophenol with chalcones (prepared by reacting acetophenone substitutes with 4-chlorothiazole-5-carbaldehyde, which was considered the main core of this study). The results showed that these  compounds have good physical properties and stability in laboratory conditions. Some spectroscopic methods such as (F.T-I.R , H-N.M.R and C-N.M.R) were used to prove the validity of the structures of these materials in addition to their purity. When testing their biological activity against two types of Gram- negative (Escherichia coil) and Gram- positive bacteria (Staphylococcus aureus). The results showed that the antibacterial activity varied, as compound M8 had the highest activity against negative bacteria, followed by compound M10, while the activity against positive bacteria was less clear compared to the antibiotics used as a control. Ciprofloxacin was used as a control sample, and its activity was higher than the prepared compounds. Despite this, the compounds can be considered promising materials for use as pharmaceutical antibiotics.