Publication Details
Abstract
The study included the use of the prepared hydrazide as a nucleophile in the formation of several organic compounds. This hydrazide was reacted with substituted benzaldehydes in the presence of ethanol as a solvent to produce hydrazones, which are nucleophiles used in the preparation of many organic compounds, where they react with 2,4-dichloroaniline to produce pharmaceutical preparations, and in the presence of pyrimidine as a solvent. The reaction was monitored by thin-layer chromatography, and the formed compounds exhibited physical changes such as color, yield, and melting point. The biological activity of some of the generated compounds was evaluated using two antibiotic-resistant bacterial isolates, Gram-positive (Staphylococcus aureus) and Gram-negative (Klebsiella pneumoniae). Fourier transform infrared spectroscopy (FTIR), hydrogen and carbon (1H&13C-NMR) spectroscopy, mass spectrometry, and quantitative C.H.N. analysis were used to confirm the accuracy of the prepared results.