Immunological Changes in Destructive Cholecystitis

This study investigates the immunological changes associated with destructive cholecystitis, a severe gallbladder inflammation that can lead to life-threatening complications. The research analyzes alterations in pro-inflammatory cytokine levels, immune cell populations, and oxidative stress markers in 32 patients with destructive cholecystitis, compared to 20 healthy controls. Elevated cytokine levels, immune cell dysregulation (reduced CD4+/CD8+ T lymphocyte ratio and increased NK cells), and increased oxidative stress (elevated MDA and decreased SOD activity) were observed. These findings highlight the critical role of the immune system in disease progression and suggest potential therapeutic strategies targeting immune modulation and oxidative stress to improve patient outcomes.