Publication Details
Abstract
During the study of the morphological and cumulative properties of heavy metal salts and aluminum compounds in the spleen of 3-month-old white outbred rats in a state of hypodynamia under experimental conditions, it was found that the spleen capsule and its trabeculae were thickened and expanded (stained in dark pink when stained with Van Gieson's dye). Since the reactive center-germinative zone has shrunk, we can see that the mantle and marginal zones have shrunk. As a result of the increase in toxic substances in the blood, the PALS zone (T-lymphocytes decreased) has shrunk, neutrophil infiltration in the red pulp has increased, the splenic bands have shrunk, the sinusoids have narrowed, and the hemolysis of erythrocytes has increased. This has led to the development of immunodeficiency, hypoplasia, and atrophy of the spleen tissue.