Assessment of Surgical Aggression in Simultaneous Operations Based on Neurohumoral Markers of Operative Stress

Relevance of the Topic. In modern surgery, the frequency of simultaneous operations is steadily increasing, especially in patients with combined abdominal pathologies. However, the cumulative physiological burden of multiple procedures performed during a single surgical session raises concerns regarding the level of surgical aggression and its systemic impact. Evaluating the degree of surgical trauma not only through clinical parameters but also via neurohumoral markers of operative stress—such as cortisol, catecholamines, and cytokines—offers a more precise understanding of the body’s response to various surgical techniques. This approach is essential for optimizing operative strategies, minimizing complications, and improving recovery outcomes in patients undergoing simultaneous surgeries.