Principles of Pathogenetic Therapy of Early Childhood Caries

Relevance of the study. After ingestion of carbohydrates, especially sucrose, the pH in biofilms adhering to teeth drops rapidly to 5.0 or lower. A lower pH leads to a so-called dysbiotic microbiome, which is characterized by an increase in the proportion of acidic biofilm species and changes in the composition of the biofilm matrix. Thus, frequent exposure to sugar leads to sustained acid production and subsequent demineralization of the tooth structure. The colonization of the oral cavity of children by microorganisms occurs through both vertical and horizontal transmission.