Clinical and Morphological Characteristics of Hepatobiliary System Lesions in Newborns with Sepsis

Lesions of the hepatobiliary system (HBS) in neonatal sepsis represent one of the key morphological markers of the systemic inflammatory response and multiple organ failure; however, their clinical and morphological features remain insufficiently systematized. Neonatal sepsis remains one of the leading causes of mortality in the neonatal period and is frequently complicated by multiple organ failure. The hepatobiliary system plays a central role in metabolic, immunological, and detoxification processes; therefore, its involvement in sepsis reflects the severity of the systemic inflammatory response. However, clinical and morphological patterns of hepatobiliary system damage in neonatal sepsis have not been sufficiently systematized.