The Use of the Products of the Bijnelli Reaction as Nucleophiles for the Preparation of New Derivatives of Azetidine and the Evaluation of the Bacterial Effectiveness of the Resulting Compounds

This study produced new azetidine derivatives by reacting derivatives of hydrazones (Benelli reaction products were used for this preparation) with chloroacetyl chloride. The produced compounds were then identified using spectroscopic techniques like infrared spectra (FT-IR) and resonance spectra (H1-NMR & C13-NMR). Among the four bacterial isolates used to evaluate the biological efficacy of some of the prepared compounds on their growth were Escherichia coli and Staphylococcus aureus. Thin layer chromatography (TLC) was employed in addition to these analyses to monitor the reactions' progress and ascertain the purity and melting points of the produced compounds.