ROLE OF FACTORS OF SYSTEM OF OXIDE OF NITROGEN IN DYNAMICS OF FORMATION AT EXPERIMENTAL ANIMALS OF THE METABOLIC SYNDROME

Research objective - to investigate a nature of activity of ferments eNOS and iNOS, expressions NO and ONO2- in serum of blood of rabbits in dynamics of formation of a metabolic syndrome.
Stuff and research methods. Experiments are made on 40 rabbits-males, mass of a body from 2 - 3,5 kg. For building of model of a metabolic syndrome in a drinking bowl of animals added 5 % solution of Saccharose, and in a forage daily mixed crystal cholesterol in a dose of mass of a body of 250 mg/kg. An animal hypodermically introduced insulin in a dose 0,1 units/100 g, every other day. Duration of experiment 2 months.  In experiment at development of a metabolic syndrome in blood the disbalance in NO-system, associating by an expression in serum of blood NO, iNOS and ONO2-, against activity oppression of endothelial NOS (eNOS) is positioned. Completion of supplies of L-arginina prevents the further formation at experimental animals МS, reduces to level of control of the maintenance in serum of blood of glucose, ChScom, S-peptide, and also dysfunction indexes of endothelium - level NO, eNOS, iNOS and ONO2-.