Publication Details
Abstract
Non-alcoholic fatty liver disease (NAFLD) is a prevalent metabolic disorder with significant links to obesity, diabetes, and atherosclerosis. This study explores the morphological changes in the liver following thyroidectomy in rabbits, establishing an experimental model for early-stage fatty liver disease. Forty female rabbits were divided into two groups: a control group (thyroid mobilization) and an experimental group (thyroidectomy). Liver samples were collected at 4 and 8 weeks post-surgery for histological analysis. By the 4th week, animals in the thyroidectomy group exhibited granular and hydropic dystrophy in hepatocytes, along with fine-droplet fatty degeneration and minimal chronic hepatitis. These changes were more pronounced by the 8th week, showing progressive necrotic and inflammatory processes and initial fibrosis signs. The findings suggest that primary hypothyroidism induced by thyroidectomy in rabbits closely mirrors the structural characteristics of NAFLD, providing insights into the pathogenesis and progression of fatty liver disease in hypothyroid conditions.