Publication Details
Abstract
We compared systemic inflammation biomarkers and disease outcomes in patients with systemic inflammatory conditions stratified by periodontal health. Group 1 (n = 50) had chronic periodontitis and a diagnosed systemic inflammatory disease; Group 2 (n = 50) had the same systemic diseases without periodontitis; a healthy control group (n = 20) provided baseline values. Clinical periodontal indices, disease activity scores, and inflammatory markers (C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), etc.) were measured at baseline and after 12 months. Patients with periodontitis showed significantly higher baseline levels of CRP, IL-6, and TNF-α than periodontitis-free patients (p < 0.01). Disease activity was worse in the periodontitis group at baseline (e.g. higher disease severity scores) and remained higher over 12 months despite standard medical therapy. The periodontitis group had a slower improvement rate and a greater proportion of patients with disease progression or flares. Systemic inflammation (CRP, IL-6) correlated positively with periodontal disease severity (p < 0.001).