Publication Details
Abstract
Introduction: Women with polycystic ovarian syndrome (PCOS) who experience spontaneous miscarriages may have high levels of homocysteine (Hcy). It has been proposed that this connection might be a significant feature of PCOS.
Aim: To evaluate the association between elevated serum homocysteine level and insulin resistance in PCOS patients who have a history of recurrent miscarriages.
Materials and Methods: This prospective study was performed at Basrah Maternity Hospital between 1st of May 2022 till the 1st of June 2024. 124 women were included in the study. 68 women diagnosed as PCOS with history of 2 or more recurrent miscarriages. PCOS was diagnosed based on Rotterdam criteria. In addition to estimation of homocysteine and Insulin Resistance with serum level of FSH, LH, Testosterone and DHEA in both groups.
Results: The age of women in the sample ranged between 28.9± 4.28 and 29.85 ± 3.69 years; most of the women had BMI between 24.79 ±2.21.and 34.71±3.45. There was no statistical difference in both groups with regard to age and number of Miscarriages but there was significant difference in relation to BMI. Moreover, there was a significant difference in regard to insulin level, insulin resistance and the level of homocysteine in PCOS which were higher than the control group.
Conclusion: Insulin resistance and hyperinsulinaemia in patients with PCOS is associated with elevated plasma homocystiene with regard to BMI which may have important implications in the short term regarding reproductive performance.