Publication Details
Abstract
The aim of this study was to investigate the morphological state of femoral bone structures in rats under conditions of glucocorticosteroid administration. The experiment was carried out on laboratory rats using a model of prolonged administration of glucocorticosteroid drugs. Morphological assessment of bone tissue was performed using standard histological methods with analysis of the compact and cancellous substances of the femur.
It was established that glucocorticosteroid administration causes pronounced structural changes in bone tissue, manifested by thinning of the cortical layer, disruption of osteonal organization, rarefaction and fragmentation of bone trabeculae, and expansion of bone marrow spaces. Signs of suppressed osteogenesis and predominance of resorptive processes were noted, indicating impairment of physiological bone remodeling.
The obtained results confirm the development of glucocorticosteroid-induced degenerative changes in femoral bone structures and emphasize the relevance of further studies of bone tissue damage mechanisms in order to develop effective preventive and therapeutic approaches.