Publication Details
Abstract
This study investigates the morphological changes in the gastric mucosa under the influence of anti-inflammatory drugs using male rats as an experimental model. Anti-inflammatory medications, particularly non-steroidal anti-inflammatory drugs (NSAIDs), are widely used in clinical practice but are known to cause adverse effects on the gastrointestinal tract.
The aim of this research is to evaluate structural alterations in the gastric mucosa following exposure to these drugs. Adult male rats were administered anti-inflammatory agents over a specified period, after which gastric tissue samples were collected for histological examination.
The results revealed significant morphological changes, including epithelial damage, mucosal erosion, inflammatory cell infiltration, and disruption of normal glandular architecture. These findings suggest that prolonged use of anti-inflammatory drugs can negatively impact the integrity of the gastric mucosa.
In conclusion, this study highlights the importance of careful use of anti-inflammatory medications and supports the need for protective strategies to minimize gastrointestinal complications.