Study of the Antitumor Activity of Colchipritis-Neo on Sarcoma 180 and Sarcoma Tumors 45

Based on the results of screening conducted on the panel of human tumors in NCI USA, the substance K-20, called colchipritis, was highly active on all tumor lines. With the intraperitoneal method of administration, its LD50 is 54 mg/kg for mice and the doses in which the drug was used to study its activity were from 3 to 5 mg/kg. When administered orally to mice, the LD50 was reduced to 1820 mg/kg, i.e., 35.7 times, and the therapeutic doses were 100 and 200 mg/kg. The LD50 of the drug for rats was 1217 mg/kg (97 times lower than that for intraperitoneal K-20), and the therapeutic doses were 60 and 30 mg/kg, but a more pronounced effect of the drug was obtained with lower doses in both mice and rats.