REPURPOSING ORLISTAT AS A FATTY ACID SYNTHASE INHIBITOR IN BREAST CANCER: IN VITRO EFFICACY, MECHANISMS, AND SYNERGY WITH DOXORUBICIN
Abeer Mansour Abdel Rasool; Ammar M. Sheet Rashid; Emad Hussein Ahmad Hassan; Abdulhameed Subhi
Objective: This study investigates the therapeutic potential of repurposing Orlistat, a potent irreversible inhibitor of fatty acid synthase (FASN), to enhance cytotoxic efficacy against breast cancer cells, both independently and in combination with doxorubicin. Method: Estrogen receptor-positiv...